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Elucidation of the Mechanism of Bone Regeneration When a Mixture of β-TCP and Autologous Bone Granules are Transplanted
https://osaka-dent.repo.nii.ac.jp/records/295
https://osaka-dent.repo.nii.ac.jp/records/2956c68f833-2409-41e4-b42d-613aef3ce022
名前 / ファイル | ライセンス | アクション |
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学位論文 (1.9 MB)
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論文内容要旨・審査結果要旨 (228.9 kB)
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Item type | 学位論文 / Thesis or Dissertation(1) | |||||
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公開日 | 2021-04-23 | |||||
本文言語 | ||||||
言語 | eng | |||||
タイトル | ||||||
タイトル | Elucidation of the Mechanism of Bone Regeneration When a Mixture of β-TCP and Autologous Bone Granules are Transplanted | |||||
著者 |
辰村, 正泰
× 辰村, 正泰× Tatsumura, Masayasu |
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キーワード | ||||||
主題Scheme | Other | |||||
主題 | autologous bone graft | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | β-TCP granules | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | micro-CT | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | picrosirius red staining | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | col-lagen | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | vWF immunostaining | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||
資源タイプ | doctoral thesis | |||||
アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | We examined the amount and maturity of collagen as a parameter for bone quality in the graft material transplanted into a rat skull bone defect model. Male SD rats were used to generate an experimental animal model of skull defects. The obtained autologous bone granules and β-TCP granules were mixed at a ratio of 1:1 to prepare a graft material that combines autologous bone with β-TCP granules. At 8 weeks after transplantation, the β-TCP+ autologous bone and the autologous bone groups showed BV/TV values, measured based on CT image analysis, significantly different from those in the β-TCP and control groups. The β-TCP+ autologous bone group exhibited the ability to form blood vessels into the graft material for a longer period of time after transplantation compared to that in the autologous bone group, as well as the elevated production of collagen into β-TCP granules during the bone formation process compared to that in the β-TCP group. | |||||
学位名 | ||||||
学位名 | 博士(歯学) | |||||
学位授与機関 | ||||||
学位授与機関識別子Scheme | kakenhi | |||||
学位授与機関識別子 | 34408 | |||||
学位授与機関名 | 大阪歯科大学 | |||||
学位授与年月日 | ||||||
学位授与年月日 | 2021-03-05 | |||||
学位授与番号 | ||||||
学位授与番号 | 甲第908号 |