| Item type |
学位論文 / Thesis or Dissertation(1) |
| 公開日 |
2021-04-23 |
| 本文言語 |
|
|
言語 |
eng |
| タイトル |
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タイトル |
Effects of plasma treatment on the bioactivity of alkali-treated ceria-stabilised zirconia/alumina nanocomposite(NANOZR) |
| 著者 |
高尾, 誠二
Takao, Seiji
|
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Ce-stabilised zirconia/alumina nanocomposite｜ plasma treatment｜implant｜ bone｜ surface roughness｜ superhydrophilicity |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_db06 |
|
資源タイプ |
doctoral thesis |
| アクセス権 |
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アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 抄録 |
|
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内容記述タイプ |
Abstract |
|
内容記述 |
Zirconia ceramics such as ceria-stabilized zirconia/alumina nanocomposites (nano-ZR) are applied as implant materials due to their excellent mechanical properties. However, surface treatment is required to obtain sufficient biocompatibility. In the present study, we explored the material surface functionalization and assessed the initial adhesion of rat bone marrow mesenchymal stem cells, their osteogenic differentiation, and production of hard tissue, on plasma-treated alkali-modified nano-ZR. Superhydrophilicity was observed on the plasma-treated surface of alkali-treated nano-ZR along with hydroxide formation and reduced surface carbon. A decreased contact angle was also observed as nano-ZR attained an appropriate wettability index. Treated samples showed higher in vitro bovine serum albumin (BSA) adsorption, initial adhesion of bone marrow and endothelial vascular cells, high alkaline phosphatase activity, and increased expression of bone differentiation-related factors. Furthermore, the in vivo performance of treated nano-ZR was evaluated by implantation in the femur of male Sprague–Dawley rats. The results showed that the amount of bone formed after the plasma treatment of alkali-modified nano-ZR was higher than that of untreated nano-ZR. Thus, induction of superhydrophilicity in nano-ZR via atmospheric pressure plasma treatment affects bone marrow and vascular cell adhesion and promotes bone formation without altering other surface properties. |
| 学位名 |
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学位名 |
博士（歯学） |
| 学位授与機関 |
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学位授与機関識別子Scheme |
kakenhi |
|
|
学位授与機関識別子 |
34408 |
|
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学位授与機関名 |
大阪歯科大学 |
| 学位授与年月日 |
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学位授与年月日 |
2021-03-05 |
| 学位授与番号 |
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学位授与番号 |
甲第913号 |
学位論文 (719.1 kB)
