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xCT阻害によるフェロトーシスは上皮間葉転換状態の口腔扁平上皮癌細胞に効果的に誘導される
https://osaka-dent.repo.nii.ac.jp/records/372
https://osaka-dent.repo.nii.ac.jp/records/372cd9806a1-4edb-4cb0-aa9f-09927609b132
| 名前 / ファイル | ライセンス | アクション |
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論文内容要旨・審査結果要旨 (335.8 kB)
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学位論文 (807 KB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||
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| 公開日 | 2023-04-04 | |||||
| 本文言語 | ||||||
| 言語 | eng | |||||
| タイトル | ||||||
| タイトル | Inhibition of xCT effectively induces ferroptosis in oral squamous cell carcinoma cells in epithelial-mesenchymal transition | |||||
| 言語 | en | |||||
| タイトル | ||||||
| タイトル | xCT阻害によるフェロトーシスは上皮間葉転換状態の口腔扁平上皮癌細胞に効果的に誘導される | |||||
| 言語 | ja | |||||
| 著者 |
髙杉, 典史
× 髙杉, 典史 |
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| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Oral squamous cell carcinoma | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Ferroptosis | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Epithelial mesenchymal transition | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | xCT | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | GPX4 | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||
| 資源タイプ | doctoral thesis | |||||
| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Ferroptosis is a newly discovered form of cell death that exhibits effective tumor suppression in various cancer cell types. Since ferroptosis efficiently decreases the viability of cancer cells undergoing epithelial-mesenchymal transition (EMT), it may exert anti-tumor effects on highly malignant oral squamous cell carcinoma (OSCC) in EMT. xCT is a subunit of a the cystine-glutamate antiporter. Ferroptosis occurs due to increased oxidative stress by inhibiting xCT. We induced EMT in OSCC cells and examined the effects of the induction of ferroptosis by inhibiting xCT in these cells. We investigated whether xCT inhibitor erastin induced ferroptosis in OSCC cells in vitro. Furthermore, we induced the EMT state in OSCC cells by the administration of transforming growth factor-β1 and examined the sensitivity of OSCC cells to ferroptosis in the presence or absence of the EMT state. Erastin induced ferroptosis in the OSCC cells. Ferroptosis-induced reductions in cell viability were greater in OSCCs of the mesenchymal state by EMT than in those in the normal state. OSCC cells in the mesenchymal state induced by EMT were highly susceptible to ferroptosis. The mesenchymal properties induced by EMT increase the malignancy of cancer cells. Therefore, therapy involving the induction of ferroptosis has potential in the treatment of advanced OSCC with invasion and metastasis. | |||||
| 言語 | en | |||||
| 学位名 | ||||||
| 言語 | ja | |||||
| 学位名 | 博士（歯学） | |||||
| 学位授与機関 | ||||||
| 学位授与機関識別子Scheme | kakenhi | |||||
| 学位授与機関識別子 | 34408 | |||||
| 言語 | ja | |||||
| 学位授与機関名 | 大阪歯科大学 | |||||
| 言語 | en | |||||
| 学位授与機関名 | Osaka Dental University | |||||
| 学位授与年月日 | ||||||
| 学位授与年月日 | 2023-03-03 | |||||
| 学位授与番号 | ||||||
| 学位授与番号 | 甲第964号 | |||||
| 権利 | ||||||
| 言語 | en | |||||
| 権利情報 | © 2023 The Author(s) | |||||
| 関連情報 | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.18905/jodu.57.1_17 | |||||
| 関連情報 | ||||||
| 関連名称 | Journal of Osaka Dental University. 2023, 57(1), p. 17-24. | |||||
