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間葉系幹細胞抽出物は歯根膜細胞の増殖を誘導する
https://osaka-dent.repo.nii.ac.jp/records/376
https://osaka-dent.repo.nii.ac.jp/records/37605387e3a-9f14-43d3-87c6-b5223e5fbf01
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論文内容要旨・審査結果要旨 (217.0 kB)
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学位論文 (304 KB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||
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| 公開日 | 2023-04-05 | |||||
| 本文言語 | ||||||
| 言語 | eng | |||||
| タイトル | ||||||
| タイトル | The extracts of mesenchymal stem cells induce the proliferation of periodontal ligament cells | |||||
| 言語 | en | |||||
| タイトル | ||||||
| タイトル | 間葉系幹細胞抽出物は歯根膜細胞の増殖を誘導する | |||||
| 言語 | ja | |||||
| 著者 |
彭, 一豪
× 彭, 一豪 |
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| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Periodontal ligament cells | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Mesenchymal stem cells | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Periodontal regeneration | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||
| 資源タイプ | doctoral thesis | |||||
| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Periodontitis is a chronic inflammatory disease caused primarily by gram-negative bacterial infection. The high incidence of this disease worldwide makes it a major oral health concern.1,2 The progression of periodontal disease leads to progressive loss of the attachment apparatus between the tooth and alveolar bone that supports the periodontal tissues, eventually leading to tooth extraction.3,4 Many therapies have been developed to regenerate periodontal tissues lost due to the disease. However, the extent of periodontal regeneration that can be achieved by these conventional regenerative therapies was limited, therefore the development of new periodontal regenerative therapies is highly desirable. The periodontal ligament is thin soft tissue that connects the teeth to alveolar bone and is responsible for physically buffering the occlusal forces applied on the teeth. In addition to its physical buffering function, the periodontal ligament has been shown to play an important role in wound healing and homeostasis of periodontal tissues by supplying progenitor/stem cells.5 It has also been demonstrated that periodontal tissue healing is dependent on the cell type that initially occupies the healing site, and that periodontal regeneration occurs only when periodontal ligament-derived cells proliferate and migrate to the wound area.5,6 The guided tissue regeneration (GTR) method has proved that periodontal regeneration occurs by inducing proliferation and migration of periodontal ligament cells to the root surface using a physical barrier membrane.7,8 This demonstrated that proliferation and migration of periodontal ligament cells are important phenomena for periodontal regeneration. Mesenchymal stem cells (MSCs) are a stem cell population with multi-differentiation potential and are used for regenerative therapies for various diseases.9,10 In periodontal disease, transplantation of MSCs has been shown to regenerate periodontal tissues in many animal studies.11–14 However, the regenerative mechanism by MSCs remains largely unknown. Recently, it has been revealed that some of the therapeutic mechanisms of MSC depend on humoral factors released by MSC, and paracrine factors derived from MSCs have attracted attention as a novel cell-free regenerative material.15,16 We previously reported that periodontal tissues are regenerated by the transplantation of culture supernatants containing paracrine factors from MSCs.17 MSC paracrine factors are stored intracellularly before being released from the cells and may be recovered as cell extracts from cultured MSC. However, the function of MSC cell extracts is still largely unknown. The purpose of this study was to investigate the effect of cell extracts from MSCs (MSC-extract) on the proliferation of periodontal ligament (PDL) cells, which play an important role in periodontal tissue regeneration. |
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| 言語 | en | |||||
| 学位名 | ||||||
| 言語 | ja | |||||
| 学位名 | 博士（歯学） | |||||
| 学位授与機関 | ||||||
| 学位授与機関識別子Scheme | kakenhi | |||||
| 学位授与機関識別子 | 34408 | |||||
| 言語 | ja | |||||
| 学位授与機関名 | 大阪歯科大学 | |||||
| 言語 | en | |||||
| 学位授与機関名 | Osaka Dental University | |||||
| 学位授与年月日 | ||||||
| 学位授与年月日 | 2023-03-03 | |||||
| 学位授与番号 | ||||||
| 学位授与番号 | 甲第968号 | |||||
| 権利 | ||||||
| 言語 | en | |||||
| 権利情報 | © 2023 The Author(s) | |||||
| 関連情報 | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.18905/jodu.57.1_119 | |||||
| 関連情報 | ||||||
| 関連名称 | Journal of Osaka Dental University. 2023, 57(1), p. 119-124. | |||||
