| Item type |
学位論文 / Thesis or Dissertation(1) |
| 公開日 |
2016-08-01 |
| 本文言語 |
|
|
言語 |
eng |
| タイトル |
|
|
タイトル |
Lidocaine protects against myocardial ischemia-reperfusion injury in anesthetized rabbits |
| 著者 |
山林, 一公
Yamabayashi, Kazutomo
|
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Lidocaine |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Myocardial protection |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Myocardial infarction |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Reperfusion injury |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Rabbit |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Lidocaine |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Myocardial protection |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Myocardial infarction |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Reperfusion injury |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Rabbit |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_db06 |
|
資源タイプ |
doctoral thesis |
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
In order to investigate the myocardial protective effect of lidocaine, we used a model of myocardial ischemia in anesthetized rabbits to study the effect on infarct size of lidocaine infusion during the first 30 minutes of reperfusion after myocardial ischemia. Japanese white rabbits anesthetized with nitrogen oxide, oxygen and pancuronium were placed on their sides. The left anterior descending coronary artery was exposed via left thoracotomy. Following a 30-minute ischemia to the coronary artery, a 30-minute infusion of lidocaine at 1.0mg/kg/h or physiological saline was started immediately after the initiation of 120-minute reperfusion. During the experiment, systemic blood pressure was continuously monitored using a catheter placed in the femoral artery, and serum lidocaine concentration was determined periodically. At the end of the experiment, the heart was isolated and treated with Evans blue dye to identify the area at risk (AAR) and the non-risk area. The areas of infarction and the risk area were determined using 1% 2,3,5-triphenyltetrazolium chloride (TTC). Although the systemic arterial pressure at 10 and 20 minutes after the coronary ligation was lower than baseline, no significant differences were observed between the lidocaine and saline groups. The AAR and non-risk areas did not differ significantly between the lidocaine and saline groups. The percentage of infarct size per AAR was 14.4% lower in animals receiving lidocaine infusion during reperfusion than in those receiving saline. These findings indicate that high-dose lidocaine infusion protects the myocardium against ischemia-reperfusion injury without affecting blood pressure during reperfusion. |
| 学位名 |
|
|
学位名 |
博士（歯学） |
| 学位授与機関 |
|
|
|
学位授与機関識別子Scheme |
kakenhi |
|
|
学位授与機関識別子 |
34408 |
|
|
学位授与機関名 |
大阪歯科大学 |
| 学位授与年月日 |
|
|
学位授与年月日 |
2013-12-25 |
| 学位授与番号 |
|
|
学位授与番号 |
乙第1581号 |
学位論文 (162.2 kB)
