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Histopathological study of experimental tooth movement in a rat model of type Ⅱ diabetes mellitus
https://osaka-dent.repo.nii.ac.jp/records/108
https://osaka-dent.repo.nii.ac.jp/records/1080ecf09d2-03e2-4515-9f58-6d1d22011731
| 名前 / ファイル | ライセンス | アクション |
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学位論文 (735.5 kB)
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論文内容要旨・審査結果要旨 (225.4 kB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||
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| 公開日 | 2016-08-01 | |||||
| 本文言語 | ||||||
| 言語 | eng | |||||
| タイトル | ||||||
| タイトル | Histopathological study of experimental tooth movement in a rat model of type Ⅱ diabetes mellitus | |||||
| 著者 |
松下, 浩子
× 松下, 浩子× Matsushita, Hiroko |
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| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Diabetes mellitus | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Pathological histology | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||
| 資源タイプ | doctoral thesis | |||||
| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Although it is thought that orthodontic treatment should be avoided in patients with diabetes mellitus, as the number of these patients increases, treatment may become necessary for some of them. We experimentally moved the teeth using the Waldo method in Goto-Kakizaki (GK) rats, an animal model of type II diabetes. On days 1, 3, 5 and 7 after initiation of tooth movement, we extracted three upper molars and the surrounding periodontal tissue en bloc, and measured the movement distance between the first (M1) and second (M2) molars. We also measured the distance between the dental crowns of the three teeth from the mesial of M1 to the distal of the third molar (M3). Afterward we made histopathologic observations. Although measurements of tooth movement and inter-crown distance from M1 to M3 showed large values on the first day after initiation of the procedure in the control group, these measurements subsequently did not change. Histopathologically, there was dilation of the periodontal ligament capillaries on the tension side on post-procedure day 1 in both the control and experimental groups. On the pressure side, marked capillary dilation was seen on post-procedure day 5 in the controls and post-procedure day 3 in the experimental group. From post-procedure day 3 the course of the collagen fibers was disrupted in the experimental group and the stainability with silver impregnation staining increased compared with the controls. Thus, in the diabetic rats there was decreased metabolic function, blood supply, and ability to form multinucleated giant cells, and the structure of collagen fibers in the connective tissue was changed. The above suggests that time is required for tooth movement in diabetes and that there is a possibility of marked breakdown of periodontal tissue. |
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| 学位名 | ||||||
| 学位名 | 博士（歯学） | |||||
| 学位授与機関 | ||||||
| 学位授与機関識別子Scheme | kakenhi | |||||
| 学位授与機関識別子 | 34408 | |||||
| 学位授与機関名 | 大阪歯科大学 | |||||
| 学位授与年月日 | ||||||
| 学位授与年月日 | 2016-03-11 | |||||
| 学位授与番号 | ||||||
| 学位授与番号 | 甲第772号 | |||||
