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Comparison of the bone forming ability of different sized-alpha tricalcium phosphate granules using a critical size defect model of the mouse calvaria
https://osaka-dent.repo.nii.ac.jp/records/120
https://osaka-dent.repo.nii.ac.jp/records/12014e87111-e52a-4626-8128-10340b17ad79
名前 / ファイル | ライセンス | アクション |
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学位論文 (675.8 kB)
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論文内容要旨・審査結果要旨 (229.1 kB)
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Item type | 学位論文 / Thesis or Dissertation(1) | |||||
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公開日 | 2016-08-01 | |||||
本文言語 | ||||||
言語 | eng | |||||
タイトル | ||||||
タイトル | Comparison of the bone forming ability of different sized-alpha tricalcium phosphate granules using a critical size defect model of the mouse calvaria | |||||
著者 |
徳田, 知子
× 徳田, 知子× Tokuda, Tomoko |
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キーワード | ||||||
主題Scheme | Other | |||||
主題 | alpha tricalcium phosphate | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | bone formation | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | particle | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | calvaria | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | hydrolysis | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||
資源タイプ | doctoral thesis | |||||
アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Alpha-tricalcium phosphate (α-TCP) has been investigated extensively as an artificial bone graft; however, the relationship between size of α-TCP particles and its bone-formation capability is not clear. In the present study, we compared the bone-formation capability of two different sized porous α-TCP particles (α-TCP200 [under 200 μm], and α-TCP600 [500–600 μm]) in critical-sized bone defects in mouse calvaria up to 12 wk after implantation. Scanning electron microscopy revealed that both particles possessed similar smooth surface with porous structure. Before implantation, inter-particle size and specific surface area of α-TCP200 were 27 μm and 0.40 m2/g and of α-TCP600 were 209 μm and 0.24m2/g, respectively. Histomorphometric analysis after implantation of the particles revealed that both particles promoted osteoconduction. At 12 wk, α-TCP200 induced superior bone formation than α-TCP600. At 4 wk, α-TCP200 showed more hydrolysis than α-TCP600. These results indicate that the size of α-TCP particles may influence their bone-formation capability in critical-sized bone defects of mouse calvaria. This effect might be partially due to the difference in the hydrolysis speed of different-sized particles. | |||||
学位名 | ||||||
学位名 | 博士(歯学) | |||||
学位授与機関 | ||||||
学位授与機関識別子Scheme | kakenhi | |||||
学位授与機関識別子 | 34408 | |||||
学位授与機関名 | 大阪歯科大学 | |||||
学位授与年月日 | ||||||
学位授与年月日 | 2016-03-11 | |||||
学位授与番号 | ||||||
学位授与番号 | 甲第784号 |