| Item type |
学位論文 / Thesis or Dissertation(1) |
| 公開日 |
2017-04-19 |
| 本文言語 |
|
|
言語 |
eng |
| タイトル |
|
|
タイトル |
Effects of gallotannin on osteoclastogenesis and the p38 MAP kinase pathway |
| 著者 |
細山, 有規子
Hosoyama, Yukiko
|
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Osteoclast｜Gallotannin｜Tannin｜p38 MAP kinase｜NFATc1 |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_db06 |
|
資源タイプ |
doctoral thesis |
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 抄録 |
|
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内容記述タイプ |
Abstract |
|
内容記述 |
We examined the effect of gallotannin on osteoclast differentiation in vitro. We found that gallotannin suppressed osteoclast differentiation in a bone marrow culture system stimulated with 1, 25 (OH)2 D3, as well as in a M-CSF/RANKL-treated BMM culture system. Also, we found that gallotannin treatment suppressed the expression of NFATc1 in RANKL-treated BMMs. To further elucidate the mechanisms underlying the suppressive effect of gallotannin on osteoclast differentiation, we examined the effects of gallotannin on RANKL- and M-CSF-mediated intracellular signaling. Although gallotannin did not affect the activation kinetics of ERK1/2 and Akt, it blunted p38 MAPK activation in RANKL-treated BMMs. We also observed the suppressive effects of gallotannin on M-CSF-induced p38 MAPK activation in BMMs that had been programmed for osteoclast differentiation by pretreatment with RANKL and low-dose M-CSF for 24 h. In other words, gallotannin specifically suppressed RANKL- and M-CSF-induced activation of the p-38 MAPK pathway. |
| 学位名 |
|
|
学位名 |
博士（歯学） |
| 学位授与機関 |
|
|
|
学位授与機関識別子Scheme |
kakenhi |
|
|
学位授与機関識別子 |
34408 |
|
|
学位授与機関名 |
大阪歯科大学 |
| 学位授与年月日 |
|
|
学位授与年月日 |
2017-03-10 |
| 学位授与番号 |
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|
学位授与番号 |
甲第795号 |
学位論文 (2.3 MB)
