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Evaluation of environmental change in the mouth with the use of spray-type oral moisturizer containing γ-PGA
https://osaka-dent.repo.nii.ac.jp/records/157
https://osaka-dent.repo.nii.ac.jp/records/157f84e1798-2168-4f60-8ca3-7131d135a93e
| 名前 / ファイル | ライセンス | アクション |
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学位論文 (211.9 kB)
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論文内容要旨・審査結果要旨 (197.3 kB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||||||
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| 公開日 | 2017-04-19 | |||||||||
| 本文言語 | ||||||||||
| 言語 | eng | |||||||||
| タイトル | ||||||||||
| タイトル | Evaluation of environmental change in the mouth with the use of spray-type oral moisturizer containing γ-PGA | |||||||||
| 著者 |
山本, 翔一
× 山本, 翔一
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| キーワード | ||||||||||
| 主題Scheme | Other | |||||||||
| 主題 | Xerostomia｜Spray-type oral moisturizer｜γ-PGA｜Dry mouth｜Stress marker | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||||||
| 資源タイプ | doctoral thesis | |||||||||
| アクセス権 | ||||||||||
| アクセス権 | open access | |||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||
| 抄録 | ||||||||||
| 内容記述タイプ | Abstract | |||||||||
| 内容記述 | Objective: This study was to evaluate the effect of new spray-type oral moisturizer containing poly-γ-glutamic acid (γ-PGA). γ-PGA can be classified as a pseudopolyamino acid, which contains only repeated glutamate units. The hygroscopic and moisturizing effects of γ-PGA were compared with HA. Cross-linked γ-PGA could absorb thousands of times more water than its own weight. Methods: 102 volunteers were randomly allocated to experimental and control groups. The experimental group (50 subjects) used this new moisturizer, the control group I (20 subjects) used sterile distilled water at normal temperature, and the control group II (32 subjects) used nothing. In experimental group, the effect of moisturizer was investigated by measuring amylase activity (salivary amylase monitor®), oral moisture (Mucus®), stimulated salivary flow rates at predetermine times (Saxon test). Results: In the amylase activity and the oral moisture, there was not a significant difference in all groups. In the stimulated salivary flow rates, there was a significant difference. When we compared the experimental group with the control group I, an increase was admitted at after 30 min (p < 0.05). When we compared the experimental group with the control group II, an increase was admitted at after 10 (p < 0.01), 20 (p < 0.05), 30 min (p < 0.05). Conclusions: New moisturizer was able to improve the environment in the mouth. Oral application of γ-PGA has a possibility to be a therapeutic strategy for treating Xerostomia. |
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| 学位名 | ||||||||||
| 学位名 | 博士（歯学） | |||||||||
| 学位授与機関 | ||||||||||
| 学位授与機関識別子Scheme | kakenhi | |||||||||
| 学位授与機関識別子 | 34408 | |||||||||
| 学位授与機関名 | 大阪歯科大学 | |||||||||
| 学位授与年月日 | ||||||||||
| 学位授与年月日 | 2017-03-10 | |||||||||
| 学位授与番号 | ||||||||||
| 学位授与番号 | 甲第799号 | |||||||||
