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Differential expression of the epithelial mesenchymal transition factors Snail, Slug, Twist, TGF-β, and E-cadherin in ameloblastoma
https://osaka-dent.repo.nii.ac.jp/records/160
https://osaka-dent.repo.nii.ac.jp/records/1600158470d-0800-4fec-91d0-1b468b58a1f4
| 名前 / ファイル | ライセンス | アクション |
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学位論文 (1.6 MB)
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論文内容要旨・審査結果要旨 (207.0 kB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||
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| 公開日 | 2017-04-19 | |||||
| 本文言語 | ||||||
| 言語 | eng | |||||
| タイトル | ||||||
| タイトル | Differential expression of the epithelial mesenchymal transition factors Snail, Slug, Twist, TGF-β, and E-cadherin in ameloblastoma | |||||
| 著者 |
栗岡, 香美
× 栗岡, 香美 |
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| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Epithelial mesenchymal transition (EMT) | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Ameloblastoma | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Immunohistochemistry | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Double immunostaining | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Snail | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Slug | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | E-cadherin | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||
| 資源タイプ | doctoral thesis | |||||
| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Epithelial mesenchymal transition (EMT), the transition of epithelial cells into motile mesenchymal cells,plays an important role in embryogenesis, cancer invasion,and metastasis. Ameloblastomas are common epithelial odontogenic tumors, occurring exclusively in the mandible with locally invasive growth. Thirty-seven ameloblastoma cases were evaluated for the involvement of EMT by immunohistochemical staining and western blotting using antibodies against Slug, Snail, Twist, TGF-b, and E-cadherin. Double immunostaining was also performed. Slug and TGF-b were expressed in the nuclei of peripheral and stellate reticulum cells of ameloblastoma nests. Twenty cases of Snail, 36 of Slug, 8 of Twist, and 19 of TGF-b showed strong expression in tumor cells in follicular and plexiform patterns. Expression of Slug and TGF-b increased in regions where the expression of E-cadherin was reduced. EMT was found to be associated with the local invasive growth of ameloblastoma. These data suggest that reduced expression of E-cadherin and over-expression of Slug, Snail, and TGF-b induce EMT. Given that ameloblastomas are characterized by local invasiveness, EMT might be related to their development. Thus, strong expression of Slug and TGF-b and reduced expression of E-cadherin might be related to the local invasiveness of ameloblastoma. |
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| 学位名 | ||||||
| 学位名 | 博士（歯学） | |||||
| 学位授与機関 | ||||||
| 学位授与機関識別子Scheme | kakenhi | |||||
| 学位授与機関識別子 | 34408 | |||||
| 学位授与機関名 | 大阪歯科大学 | |||||
| 学位授与年月日 | ||||||
| 学位授与年月日 | 2017-03-10 | |||||
| 学位授与番号 | ||||||
| 学位授与番号 | 甲第802号 | |||||
