WEKO3
アイテム
Effect of hyaluronan on osteoclast differentiation in mouse bone marrow-derived cells cocultured with primary osteoblasts
https://osaka-dent.repo.nii.ac.jp/records/17
https://osaka-dent.repo.nii.ac.jp/records/172ee708a6-d651-4805-9e29-f8ce5bb570ab
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
学位論文 (322.4 kB)
|
.png)
|
|
|
論文内容要旨・審査結果要旨 (180.6 kB)
|
|
| Item type | 学位論文 / Thesis or Dissertation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2016-08-01 | |||||
| 本文言語 | ||||||
| 言語 | eng | |||||
| タイトル | ||||||
| タイトル | Effect of hyaluronan on osteoclast differentiation in mouse bone marrow-derived cells cocultured with primary osteoblasts | |||||
| 著者 |
廣⽥, 秀逸
× 廣⽥, 秀逸× Hirota, Shuitsu |
|||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Hyaluronan | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Coculture | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Osteoclast differentiation | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Hyaluronan | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Coculture | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Osteoclast differentiation | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||
| 資源タイプ | doctoral thesis | |||||
| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Hyaluronan (HA) is widely used as a disease-modifying drug to reduce pain in patients with osteoarthritis. We investigated whether the commercially available HA product Artz^[○!R] contributes to bone regeneration. To assess whether exogenous HA influences bone resorption and formation, we examined osteoclast differentiation in mouse bone marrow-derived cells co- cultured with primary mouse calvarial osteoblasts, and also analyzed the proliferation and adhesion of these cells. Coculture of osteoblasts and bone marrow cells in the presence of HA resulted in decreased osteoclast differentiation. Cellular proliferation of osteoblasts and bone marrow cells in the presence of HA was significantly greater than in the absence of HA. However, adhesion of bone marrow cells was decreased by HA. The increased proliferation of osteoblasts and decreased number of attached bone marrow cells in the presence of HA lead to an imbalance between the number of these cells, resulting in suppressed osteoclast differentiation. | |||||
| 学位名 | ||||||
| 学位名 | 博士（歯学） | |||||
| 学位授与機関 | ||||||
| 学位授与機関識別子Scheme | kakenhi | |||||
| 学位授与機関識別子 | 34408 | |||||
| 学位授与機関名 | 大阪歯科大学 | |||||
| 学位授与年月日 | ||||||
| 学位授与年月日 | 2015-03-06 | |||||
| 学位授与番号 | ||||||
| 学位授与番号 | 甲第751号 | |||||
