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Periodontal regeneration induced by porous alpha-tricalcium phosphate with immobilized basic fibroblast growth factor in a canine model of 2-wall periodontal defects
https://osaka-dent.repo.nii.ac.jp/records/176
https://osaka-dent.repo.nii.ac.jp/records/1761473f576-8490-47fa-8b1a-53f848a981ce
| 名前 / ファイル | ライセンス | アクション |
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学位論文 (1.3 MB)
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論文内容要旨・審査結果要旨 (226.2 kB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||||||
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| 公開日 | 2018-05-17 | |||||||||
| 本文言語 | ||||||||||
| 言語 | eng | |||||||||
| タイトル | ||||||||||
| タイトル | Periodontal regeneration induced by porous alpha-tricalcium phosphate with immobilized basic fibroblast growth factor in a canine model of 2-wall periodontal defects | |||||||||
| 著者 |
松瀬, 和也
× 松瀬, 和也
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| キーワード | ||||||||||
| 主題Scheme | Other | |||||||||
| 主題 | Alpha-tricalcium phosphate | |||||||||
| キーワード | ||||||||||
| 主題Scheme | Other | |||||||||
| 主題 | Basic fibroblast growth factor | |||||||||
| キーワード | ||||||||||
| 主題Scheme | Other | |||||||||
| 主題 | Canine2-wall periodontal defect model | |||||||||
| キーワード | ||||||||||
| 主題Scheme | Other | |||||||||
| 主題 | Immobilization | |||||||||
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| 主題Scheme | Other | |||||||||
| 主題 | Periodontal regeneration | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||||||
| 資源タイプ | doctoral thesis | |||||||||
| アクセス権 | ||||||||||
| アクセス権 | open access | |||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||
| 抄録 | ||||||||||
| 内容記述タイプ | Abstract | |||||||||
| 内容記述 | We evaluated the effect of porous alpha-tricalcium phosphate (α-TCP) with immobilized basic fibroblast growth factor (bFGF) on periodontal regeneration in a canine model of 2-wall periodontal defects. Identical bone defects were made in the canine mandible; six defects in each animal were filled with porous α-TCP with bFGF bound via heparin (bFGF group), and the remaining defects were filled with unmodified porous α-TCP (control group). Micro-computed tomography and histological evaluation were performed at 2, 4, and 8 weeks post-implantation. The bone mineral content of the bFGF group was higher than that of the control group at 2 and 4 weeks (p < 0.05). Histological evaluation at 2 weeks post-implantation revealed degradation of the porous α-TCP, and bone had formed on the surface of α-TCP particles in the bFGF group. Some of these collagen fibers connected the newly formed cementum with the alveolar bone, revealing the formation of new periodontal ligaments with Sharpey's fibers. At 8 weeks, continuous cortical bone with a Haversian structure covered the top of the bone defects in the bFGF group. These findings indicate that porous α-TCP with immobilized bFGF could promote periodontal regeneration at the early regeneration phase in a canine model of 2-wall periodontal defects. | |||||||||
| 学位名 | ||||||||||
| 学位名 | 博士（歯学） | |||||||||
| 学位授与機関 | ||||||||||
| 学位授与機関識別子Scheme | kakenhi | |||||||||
| 学位授与機関識別子 | 34408 | |||||||||
| 学位授与機関名 | 大阪歯科大学 | |||||||||
| 学位授与年月日 | ||||||||||
| 学位授与年月日 | 2018-03-09 | |||||||||
| 学位授与番号 | ||||||||||
| 学位授与番号 | 甲第814号 | |||||||||
