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歯槽骨骨密度を用いた薬剤関連顎骨壊死のリスク評価
https://osaka-dent.repo.nii.ac.jp/records/2000105
https://osaka-dent.repo.nii.ac.jp/records/2000105b2c607aa-3efd-4e71-9a96-9fa2577b516e
| 名前 / ファイル | ライセンス | アクション |
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論文内容要旨・審査結果要旨 (229 KB)
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学位論文 (1.6 MB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||||||||
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| 公開日 | 2024-06-01 | |||||||||||
| 本文言語 | ||||||||||||
| 言語 | eng | |||||||||||
| タイトル | ||||||||||||
| タイトル | Risk assessment of medication-related osteonecrosis of the jaw by alveolar bone mineral density | |||||||||||
| 言語 | en | |||||||||||
| タイトル | ||||||||||||
| タイトル | 歯槽骨骨密度を用いた薬剤関連顎骨壊死のリスク評価 | |||||||||||
| 言語 | ja | |||||||||||
| 著者 |
濱田, 翔央
× 濱田, 翔央
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| キーワード | ||||||||||||
| 言語 | en | |||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | Medication-related osteonecrosis of the jaw (MRONJ) | |||||||||||
| キーワード | ||||||||||||
| 言語 | en | |||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | Alveolar bone mineral density (al-BMD) | |||||||||||
| キーワード | ||||||||||||
| 言語 | en | |||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | Bone-modifying agent (BMA) | |||||||||||
| キーワード | ||||||||||||
| 言語 | en | |||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | Anti-resorptive agent (ARA) | |||||||||||
| キーワード | ||||||||||||
| 言語 | en | |||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | Osteoporosis | |||||||||||
| 資源タイプ | ||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||||||||
| 資源タイプ | doctoral thesis | |||||||||||
| アクセス権 | ||||||||||||
| アクセス権 | open access | |||||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||||
| 抄録 | ||||||||||||
| 内容記述タイプ | Abstract | |||||||||||
| 内容記述 | Objectives: Osteosclerosis and a high bone mineral density (BMD) have been proposed as risk factors for medication-related osteonecrosis of the jaw (MRONJ). In the present study, we measured the alveolar BMD (al-BMD) of teeth indicated for extraction on dental radiographs using BMD analysis software and investigated the relationship between al-BMD and MRONJ. Materials and Methods: We measured al-BMD on dental radiographs using BMD analysis software (Bone Right®) in 100 bone-modifying agent (BMA)-treated patients who visited our department for tooth extraction between November 2020 and May 2023. Fifteen patients treated with BMA for more than 4 years underwent tooth extraction 2 months after their cessation. Results: In 100 patients who underwent tooth extraction, only one patient on high-dose anti-resorptive agents (ARAs) developed MRONJ. al-BMD was significantly higher in MRONJ patients than in non-MRONJ patients. No significant change was observed in al-BMD before and 2 months after the cessation of BMA. Conclusion: Patients who developed MRONJ after tooth extraction had higher al-BMD before tooth extraction, and a relationship between MRONJ and osteosclerosis cannot be ruled out. On the other hand, al-BMD did not change before and after the cessation of BMA, and MRONJ did not occur in patients treated with low-dose ARAs, suggesting that the cessation of BMA is not necessary. |
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| 言語 | en | |||||||||||
| 学位名 | ||||||||||||
| 言語 | ja | |||||||||||
| 学位名 | 博士（歯学） | |||||||||||
| 学位授与機関 | ||||||||||||
| 学位授与機関識別子Scheme | kakenhi | |||||||||||
| 学位授与機関識別子 | 34408 | |||||||||||
| 言語 | ja | |||||||||||
| 学位授与機関名 | 大阪歯科大学 | |||||||||||
| 言語 | en | |||||||||||
| 学位授与機関名 | Osaka Dental University | |||||||||||
| 学位授与年月日 | ||||||||||||
| 学位授与年月日 | 2024-03-01 | |||||||||||
| 学位授与番号 | ||||||||||||
| 学位授与番号 | 甲第993号 | |||||||||||
| 権利 | ||||||||||||
| 言語 | en | |||||||||||
| 権利情報 | © 2024 The Author(s) | |||||||||||
| 関連情報 | ||||||||||||
| 識別子タイプ | DOI | |||||||||||
| 関連識別子 | https://doi.org/10.18905/jodu.58.1_153 | |||||||||||
| 関連情報 | ||||||||||||
| 関連名称 | Journal of Osaka Dental University. 2024, 58(1), p. 153-164. | |||||||||||
