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ヒト歯肉由来線維芽細胞のTIMP-1産生に対するPDGF-bbの影響
https://osaka-dent.repo.nii.ac.jp/records/2000126
https://osaka-dent.repo.nii.ac.jp/records/20001262b9bc53d-7c68-4a3f-8c7c-05cc2a3e02e0
| 名前 / ファイル | ライセンス | アクション |
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本文内容要旨・審査結果要旨 (252 KB)
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学位論文 (527 KB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||||||||
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| 公開日 | 2024-06-27 | |||||||||||
| 本文言語 | ||||||||||||
| 言語 | eng | |||||||||||
| タイトル | ||||||||||||
| タイトル | Effects of Platelet-derived Growth Factor-bb on Tissue Inhibitor of Metalloproteinase-1 Production in Human Gingival-derived Fibroblasts | |||||||||||
| 言語 | en | |||||||||||
| タイトル | ||||||||||||
| タイトル | ヒト歯肉由来線維芽細胞のTIMP-1産生に対するPDGF-bbの影響 | |||||||||||
| 言語 | ja | |||||||||||
| 著者 |
森﨑, 歩
× 森﨑, 歩
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| キーワード | ||||||||||||
| 言語 | en | |||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | PDGF-bb | |||||||||||
| キーワード | ||||||||||||
| 言語 | en | |||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | TIMP-1 | |||||||||||
| キーワード | ||||||||||||
| 言語 | en | |||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | Human gingival fibroblasts | |||||||||||
| 資源タイプ | ||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||||||||
| 資源タイプ | doctoral thesis | |||||||||||
| アクセス権 | ||||||||||||
| アクセス権 | open access | |||||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||||
| 抄録 | ||||||||||||
| 内容記述タイプ | Abstract | |||||||||||
| 内容記述 | Matrix metalloproteinases degrade the extracellular matrix during remodeling, and their activity is regulated by tissue metalloproteinase inhibitors (TIMPs). Platelet-derived growth factor (PDGF) is produced in periodontal tissue and is an important regulator of wound healing and tissue repair. ERK1/2, members of the MAPK family, are intracellular signaling substance kinases involved in TIMP-1 production. To elucidate the mechanisms underlying connective tissue remodeling, the present study investigated the relationship between PDGF-bb-stimulated TIMP-1 production and ERK1/2 phosphorylation in human gingival fibroblasts (HGF). TIMP-1 production increased in a PDGF-bb concentration-dependent manner. PDGF-bb-induced increases in TIMP-1 were further enhanced by the p38α/β inhibitor SB239063 and p38α-siRNA. The PDGF-bb stimulation also induced the phosphorylation of ERK1/2. In contrast, the treatment with the p38-MAPK inhibitor SB203580 suppressed the phosphorylation of ERK1/2. These results suggest that PDGF-bb induced the production of TIMP-1 through the ERK1/2-activated signal transduction pathway in HGF. In addition, signaling cross-talk between p38α and ERK1/2 was involved in ERK1/2 activation, suggesting that ERK1/2 activation is coordinately regulated by p38α. | |||||||||||
| 言語 | en | |||||||||||
| 学位名 | ||||||||||||
| 言語 | ja | |||||||||||
| 学位名 | 博士（歯学） | |||||||||||
| 学位授与機関 | ||||||||||||
| 学位授与機関識別子Scheme | kakenhi | |||||||||||
| 学位授与機関識別子 | 34408 | |||||||||||
| 言語 | ja | |||||||||||
| 学位授与機関名 | 大阪歯科大学 | |||||||||||
| 言語 | en | |||||||||||
| 学位授与機関名 | Osaka Dental University | |||||||||||
| 学位授与年月日 | ||||||||||||
| 学位授与年月日 | 2024-03-27 | |||||||||||
| 学位授与番号 | ||||||||||||
| 学位授与番号 | 乙第1664号 | |||||||||||
| 権利 | ||||||||||||
| 言語 | en | |||||||||||
| 権利情報 | © 2023 Nano Biomedical Society | |||||||||||
| 権利 | ||||||||||||
| 言語 | en | |||||||||||
| 権利情報Resource | https://creativecommons.org/licenses/by-nd/4.0/ | |||||||||||
| 権利情報 | Creative Commons Attribution-NoDerivs 4.0 International | |||||||||||
| 関連情報 | ||||||||||||
| 識別子タイプ | DOI | |||||||||||
| 関連識別子 | https://doi.org/10.11344/nano.15.44 | |||||||||||
| 関連情報 | ||||||||||||
| 関連名称 | Nano Biomedicine. 2023, 15(2), p. 44-50. | |||||||||||
