WEKO3
アイテム
下顎骨骨欠損モデルにおけるコラーゲンモデルポリペプチド/αリン酸三カルシウムスポンジによる骨形成
https://osaka-dent.repo.nii.ac.jp/records/2000130
https://osaka-dent.repo.nii.ac.jp/records/2000130ea04180b-d7cc-4210-99d7-d44dda6c8ea3
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
論文内容要旨・審査結果要旨 (253 KB)
|
|
|
|
学位論文 (835 KB)
|
|
| Item type | 学位論文 / Thesis or Dissertation(1) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 公開日 | 2024-08-28 | |||||||||||
| 本文言語 | ||||||||||||
| 言語 | eng | |||||||||||
| タイトル | ||||||||||||
| タイトル | Bone formation with a collagen model polypeptides/alpha- tricalcium phosphate sponge in a mandibular canine defect model | |||||||||||
| 言語 | en | |||||||||||
| タイトル | ||||||||||||
| タイトル | 下顎骨骨欠損モデルにおけるコラーゲンモデルポリペプチド/αリン酸三カルシウムスポンジによる骨形成 | |||||||||||
| 言語 | ja | |||||||||||
| 著者 |
譚, 程
× 譚, 程
|
|||||||||||
| キーワード | ||||||||||||
| 言語 | en | |||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | Bone formation | |||||||||||
| キーワード | ||||||||||||
| 言語 | en | |||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | collagen model polypeptides | |||||||||||
| キーワード | ||||||||||||
| 言語 | en | |||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | alpha- tricalcium phosphate | |||||||||||
| 資源タイプ | ||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||||||||
| 資源タイプ | doctoral thesis | |||||||||||
| アクセス権 | ||||||||||||
| アクセス権 | open access | |||||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||||
| 抄録 | ||||||||||||
| 内容記述タイプ | Abstract | |||||||||||
| 内容記述 | We investigated the effect of synthesized collagen model polypeptides consisting of a proline-hydroxyproline-glycine (poly(PHG)) sequence combined with porous alpha-tricalcium phosphate (α-TCP) particles on bone formation in a mandibular canine defect model. The porous α-TCP particles were mixed with a poly(PHG) solution, and the obtained sponge was then cross-linked and analyzed by scanning electron microscopy. The optimal mixing concentration of α-TCP granules and the poly(PHG) solution was decided to be 0.15g/mL by compression testing. The osteoblastic differentiation with the ALP activity of human mesenchymal stromal cells (hMSCs) cultured on the poly(PHG)/α-TCP was slightly greater than that of hMSCs cultured on the poly(PHG). Mandibular defects were analyzed in healthy beagles using micro-computed tomography and histological evaluation. At 2 and 4 weeks, the volume density of new bone was grater in the poly(PHG)/α-TCP group than in the group with only poly(PHG) (p < 0.05); however, there was no difference at 8 weeks (p > 0.05). Histological evaluation at 4 weeks after implantation revealed that the poly(PHG) had degraded and that newly formed bone was present on the surface of the α-TCP particles. This study demonstrates that the composite created using porous α-TCP particles and poly(PHG) is sufficiently adaptable for treating the mandibular defect model. | |||||||||||
| 言語 | en | |||||||||||
| 学位名 | ||||||||||||
| 言語 | ja | |||||||||||
| 学位名 | 博士（歯学） | |||||||||||
| 学位授与機関 | ||||||||||||
| 学位授与機関識別子Scheme | kakenhi | |||||||||||
| 学位授与機関識別子 | 34408 | |||||||||||
| 言語 | ja | |||||||||||
| 学位授与機関名 | 大阪歯科大学 | |||||||||||
| 言語 | en | |||||||||||
| 学位授与機関名 | Osaka Dental University | |||||||||||
| 学位授与年月日 | ||||||||||||
| 学位授与年月日 | 2024-06-26 | |||||||||||
| 学位授与番号 | ||||||||||||
| 学位授与番号 | 乙第1668号 | |||||||||||
| 権利 | ||||||||||||
| 言語 | en | |||||||||||
| 権利情報 | © 2023 The Author(s) | |||||||||||
| 関連情報 | ||||||||||||
| 識別子タイプ | DOI | |||||||||||
| DOI | https://doi.org/10.18905/jodu.57.2_223 | |||||||||||
| 関連情報 | ||||||||||||
| 掲載情報 | Journal of Osaka Dental University. 2023, 57(2), p. 223-231. | |||||||||||
