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Epigallocatechin Gallate-Modified Gelatins with Different Compositions Alter the Quality of Regenerated Bones
https://osaka-dent.repo.nii.ac.jp/records/206
https://osaka-dent.repo.nii.ac.jp/records/20679b65c65-d88b-457e-ab0c-129a8b4bfbe6
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
学位論文 (6.1 MB)
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論文内容要旨・審査結果要旨 (226.3 kB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2019-05-17 | |||||
| 本文言語 | ||||||
| 言語 | eng | |||||
| タイトル | ||||||
| タイトル | Epigallocatechin Gallate-Modified Gelatins with Different Compositions Alter the Quality of Regenerated Bones | |||||
| 著者 |
原, 瑛紀
× 原, 瑛紀× Hara, Eiki |
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| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | bone quality | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | EGCG | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | bone formation | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | gelatin | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | collagen | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | FTIR imaging | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||
| 資源タイプ | doctoral thesis | |||||
| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Bone quality is a significant indicator of the result of bone treatments. However, information regarding the quality of regenerated bones is limited. The study investigates the effect of different compositions of vacuum heated epigallocatechin gallate-modified gelatins sponge (vhEGCG-GS) on the quality of regenerated bones in critical size defects (9 mm) of rat calvariae. Five different compositions of vhEGCG-GSs containing the same amount of EGCG and different amounts of gelatin were tested. Following four weeks after implantation, the harvested regenerated bones were evaluated by using micro-computed tomography analysis, histological evaluation (hematoxylin-eosin and Villaneueva Goldner staining), picrosirius red-staining with polarized microscopic observation for collagen maturation, and Fourier transform infrared spectroscopy microscopy and imaging analysis for mineral-matrix ratio. The results indicated that increasing content of gelatin in the vhEGCG-GSs promoted bone and osteoid formation but yielded porous bones. Furthermore, tissue mineral density decreased and the maximum mineral-matrix ratio increased. In contrast, vhEGCG-GSs containing smaller amount of gelatin formed mature collagen matrix in the regenerated bones. These results suggest that the alteration of composition of vhEGCG-GSs affected the bone forming capability and quality of regenerated bone and provides valuable insight for the fabrication of new bone substitute materials. | |||||
| 学位名 | ||||||
| 学位名 | 博士（歯学） | |||||
| 学位授与機関 | ||||||
| 学位授与機関識別子Scheme | kakenhi | |||||
| 学位授与機関識別子 | 34408 | |||||
| 学位授与機関名 | 大阪歯科大学 | |||||
| 学位授与年月日 | ||||||
| 学位授与年月日 | 2019-03-08 | |||||
| 学位授与番号 | ||||||
| 学位授与番号 | 甲第834号 | |||||
