| Item type |
学位論文 / Thesis or Dissertation(1) |
| 公開日 |
2022-05-13 |
| 本文言語 |
|
|
言語 |
eng |
| タイトル |
|
|
タイトル |
UV/ozone irradiation manipulates immune response for antibacterial activity and bone regeneration on titanium |
| 著者 |
楊, 元元
Yang, Yuanyuan
|
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Immune response｜UV/ozone irradiation｜Immunomodulatory ｜antibacterial ｜Osteoimmunomodulation |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_db06 |
|
資源タイプ |
doctoral thesis |
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 抄録 |
|
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内容記述タイプ |
Abstract |
|
内容記述 |
The immunomodulatory antibacterial activity and osteoimmunomodulatory properties of implantable bio- materials significantly influence bone regeneration. Various types of ultraviolet (UV) instrument are currently in use to greatly enhance the antibacterial activity and osteoconductive capability of titanium, it remains unclear how UV treatment modulates immune response. Compared to traditional UV treatment, the combination of low- dose ozone with UV irradiation is considered a new option to give benefits to surface modification and reduce the drawbacks of UV and ozone individually. Herein, the aim of this study was to elucidate the immune-modulatory properties of macrophages on UV/ozone-irradiated titanium that serve as defense against S. aureus and the crosstalk between immune cells and osteoblasts. Three different cell and bacteria co-culture systems were developed in order to investigate the race between host cells and bacteria to occupy the surface. In vitro immunological experiments indicated that UV/ozone irradiation significantly enhanced the phagocytic and bactericidal activity of macrophages against S. aureus. Further, in vitro and in vivo studies evidenced the favorable osteoimmune environment for osteogenic differentiation and bone formation. This research suggests vital therapeutic potential of UV/ozone irradiation for preventing the biomaterial-associated infections and achieving favorable bone formation simultaneously. |
| 学位名 |
|
|
学位名 |
博士（歯学） |
| 学位授与機関 |
|
|
|
学位授与機関識別子Scheme |
kakenhi |
|
|
学位授与機関識別子 |
34408 |
|
|
学位授与機関名 |
大阪歯科大学 |
| 学位授与年月日 |
|
|
学位授与年月日 |
2022-03-04 |
| 学位授与番号 |
|
|
学位授与番号 |
甲第917号 |
学位論文 (1.6 MB)
