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  1. 学位論文
  2. 歯学研究科
  3. 令和3年度
  4. 課程博士

Comparison of Osteogenic Potentials of Dental Pulp and Bone Marrow Mesenchymal Stem Cells Using the New Cell Transplantation Platform,CellSaic, in a Rat Congenital Cleft-Jaw Model

https://osaka-dent.repo.nii.ac.jp/records/320
https://osaka-dent.repo.nii.ac.jp/records/320
9b047b20-85ea-4fb9-b8ee-edc92f6d2b43
名前 / ファイル ライセンス アクション
kou_922_txt_最適化.pdf 学位論文 (1.3 MB)
kou_922.pdf 論文内容要旨・審査結果要旨 (227.9 kB)
Item type 学位論文 / Thesis or Dissertation(1)
公開日 2022-05-13
本文言語
言語 eng
タイトル
タイトル Comparison of Osteogenic Potentials of Dental Pulp and Bone Marrow Mesenchymal Stem Cells Using the New Cell Transplantation Platform,CellSaic, in a Rat Congenital Cleft-Jaw Model
著者 呂, 金釗

× 呂, 金釗

呂, 金釗

ja-Kana ロ, キンショウ

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Lyu, JinZhao

× Lyu, JinZhao

en Lyu, JinZhao

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キーワード
主題Scheme Other
主題 stem cells|Cellnest™|CellSaic| rDPSCs|rBMSCs|regeneration|osteogenic differentiation|bone repair|rat congenital cleft-jaw model
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_db06
資源タイプ doctoral thesis
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
抄録
内容記述タイプ Abstract
内容記述 Scaffolds stimulate cell proliferation and differentiation and play major roles in providing growth and nutrition factors in the repair of bone defects. We used the recombinant peptide Cellnest™to prepare the three-dimensional stem cell complex, CellSaic, and evaluated whether CellSaic con taining rat dental pulp stem cells (rDPSCs) was better than that containing rat bone marrow stem cells (rBMSCs). rDPSC-CellSaic or rBMSC-CellSaic, cultured with or without osteogenic induction medium, formed the experimental and control groups, respectively. Osteoblast differentiation was evaluated in vitro and transplanted into a rat model with a congenital jaw fracture. Specimens were collected and evaluated by microradiology and histological analysis. In the experimental group, the amount of calcium deposits, expression levels of bone-related genes (RUNX2, ALP, BSP, and COL1),and volume of mineralized tissue, were significantly higher than those in the control group (p < 0.05).Both differentiated and undifferentiated rDPSC-CellSaic and only the differentiated rBMSC-CellSaic could induce the formation of new bone tissue. Overall, rBMSC-CellSaic and rDPSC-CellSaic made with Cellnest™ as a scaffold, provide excellent support for promoting bone regeneration in rat mandibular congenital defects. Additionally, rDPSC-CellSaic seems a better source for craniofacial bone defect repair than rBMSC-CellSaic, suggesting the possibility of using DPSCs in bone tissue regenerative therapy
学位名
学位名 博士(歯学)
学位授与機関
学位授与機関識別子Scheme kakenhi
学位授与機関識別子 34408
学位授与機関名 大阪歯科大学
学位授与年月日
学位授与年月日 2022-03-04
学位授与番号
学位授与番号 甲第922号
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