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グルコース濃度の変動が歯根膜細胞の骨芽細胞分化に及ぼす影響
https://osaka-dent.repo.nii.ac.jp/records/359
https://osaka-dent.repo.nii.ac.jp/records/359d1242073-495c-4300-b904-e67e40b3c327
| 名前 / ファイル | ライセンス | アクション |
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論文内容要旨・審査結果要旨 (194.6 kB)
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学位論文 (812 KB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||
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| 公開日 | 2023-04-04 | |||||
| 本文言語 | ||||||
| 言語 | eng | |||||
| タイトル | ||||||
| タイトル | Effect of fluctuating glucose concentration on osteogenic differentiation of periodontal ligament cells | |||||
| 言語 | en | |||||
| タイトル | ||||||
| タイトル | グルコース濃度の変動が歯根膜細胞の骨芽細胞分化に及ぼす影響 | |||||
| 言語 | ja | |||||
| 著者 |
鄧, 信
× 鄧, 信 |
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| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Periodontal ligament cells | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Glucose | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Osteogenic differentiation | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||
| 資源タイプ | doctoral thesis | |||||
| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Although fluctuations in glucose concentration have been reported to regulate osteoblast differentiation, the effect on periodontal ligament cells is not clear. We investigated the effect of fluctuating glucose concentrations on the cellular functions of periodontal ligament cells (PDLCs). Variations in glucose concentration were examined in four ways: a group was incubated in 100 mg/dL glucose for 14 days; a group was incubated in 100 mg/dL glucose for 7 days, the solution was replaced with 0 mg/dL glucose, and the group was incubated for another 7 days; a group was incubated in 0 mg/dL glucose for 7 days, the solution was replaced with 100 mg/dL glucose, and the group was incubated for another 7 days; and a group was incubated in 0 mg/dL glucose for 14 days. We evaluated the osteogenic differentiation capacity by alkaline phosphatase (ALP) activity, ALP staining, calcium deposition and alizarin red staining after 14 days of culturing. We found that the osteogenic differentiation of PDLCs was enhanced in the presence of glucose, suggesting that it regulates the differentiation of PDLCs, especially in the early stage of differentiation. | |||||
| 言語 | en | |||||
| 学位名 | ||||||
| 言語 | ja | |||||
| 学位名 | 博士（歯学） | |||||
| 学位授与機関 | ||||||
| 学位授与機関識別子Scheme | kakenhi | |||||
| 学位授与機関識別子 | 34408 | |||||
| 言語 | ja | |||||
| 学位授与機関名 | 大阪歯科大学 | |||||
| 言語 | en | |||||
| 学位授与機関名 | Osaka Dental University | |||||
| 学位授与年月日 | ||||||
| 学位授与年月日 | 2023-03-03 | |||||
| 学位授与番号 | ||||||
| 学位授与番号 | 甲第951号 | |||||
| 権利 | ||||||
| 言語 | en | |||||
| 権利情報 | © 2023 The Author(s) | |||||
| 関連情報 | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.18905/jodu.57.1_25 | |||||
| 関連情報 | ||||||
| 関連名称 | Journal of Osaka Dental University. 2023, 57(1), p. 25-29. | |||||
