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口腔粘膜の上皮性異形成におけるCK13, CK17, CK19, Ki 67, p53, p63, p21, p27 およびCyclin D1に関する免疫組織化学的検討
https://osaka-dent.repo.nii.ac.jp/records/371
https://osaka-dent.repo.nii.ac.jp/records/371540bded7-f80d-4534-bdce-ae700b9b0ebf
| 名前 / ファイル | ライセンス | アクション |
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論文内容要旨・審査結果要旨 (247.6 kB)
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学位論文 (760 KB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||
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| 公開日 | 2023-04-04 | |||||
| 本文言語 | ||||||
| 言語 | eng | |||||
| タイトル | ||||||
| タイトル | Immunohistochemical study of CK13, CK17, CK19, Ki-67, p53, p63, p21, p27 and Cyclin D1 in oral epithelial dysplasia | |||||
| 言語 | en | |||||
| タイトル | ||||||
| タイトル | 口腔粘膜の上皮性異形成におけるCK13, CK17, CK19, Ki 67, p53, p63, p21, p27 およびCyclin D1に関する免疫組織化学的検討 | |||||
| 言語 | ja | |||||
| 著者 |
北吉, 麻理奈
× 北吉, 麻理奈 |
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| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Oral epithelial dysplasia | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Ki-67 | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | p53 | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | p63 | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | p27 | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||
| 資源タイプ | doctoral thesis | |||||
| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | In the current World Health Organization (WHO) classification, oral epithelial dysplasia (OED) is classified using a two- or three-grade system. However, no useful auxiliary diagnostic method for determining the OED grade of specimens by this system has yet been established. In this study, specimens of not only OED, but also epithelial hyperplasia (Hp) and oral squamous cell carcinoma (OSCC) were examined immunohistochemically to investigate expression levels/rates of various antibodies. Six specimens of Hp, 13 of mild epithelial dysplasia (MiD), 11 of moderate epithelial dysplasia (MoD), 11 of severe epithelial dysplasia (SD), and 9 of OSCC obtained from the First Department of Oral and Maxillofacial Surgery at Osaka Dental University Hospital were examined immunohistochemically to determine the expression levels of CK13, CK17, CK19, Ki-67, p53, p63, p21, p27 and cyclin D1. The dysplasia grade was negatively correlated with expression of CK13 and CK17. As the dysplasia grade increased, expression rates of Ki-67, p53, p63, p21 and cyclin D1 increased, while the expression rate of p27 decreased. The expression rate of Ki-67 differed significantly between SD and OSCC, as did the expression of p53 between MoD and SD as well as between SD and OSCC. The expression rate of p63 differed significantly between MiD and MoD as well as between MoD and SD, as did the expression rate of p27 between SD and OSCC (p < 0.05). These results suggest that not only CK13, CK17, Ki-67 and p53, but also p63, p21, p27 and cyclin D1 may be linked to dysplasia. The results also suggest that calculation of Ki-67, p53, p63 and p27 expression rates could be used for OED grading and auxiliary diagnosis of OSCC. | |||||
| 言語 | en | |||||
| 学位名 | ||||||
| 言語 | ja | |||||
| 学位名 | 博士（歯学） | |||||
| 学位授与機関 | ||||||
| 学位授与機関識別子Scheme | kakenhi | |||||
| 学位授与機関識別子 | 34408 | |||||
| 言語 | ja | |||||
| 学位授与機関名 | 大阪歯科大学 | |||||
| 言語 | en | |||||
| 学位授与機関名 | Osaka Dental University | |||||
| 学位授与年月日 | ||||||
| 学位授与年月日 | 2023-03-03 | |||||
| 学位授与番号 | ||||||
| 学位授与番号 | 甲第963号 | |||||
| 権利 | ||||||
| 言語 | en | |||||
| 権利情報 | © 2023 The Author(s) | |||||
| 関連情報 | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.18905/jodu.57.1_107 | |||||
| 関連情報 | ||||||
| 関連名称 | Journal of Osaka Dental University. 2023, 57(1), p. 107-117. | |||||
